It is 2016, Vanessa is selling her blood at a blood clinic for a few extra dollars. Dylan waits for her outside. Newsflashes about a volcanic eruption near Yellowstone National Park. Meanwhile, a vampire who has stolen blood from the clinic is drinking Vanessa’s blood. He gets ill and vomits blood.
Dmitri and Rebecca await for their blood delivery. Dmitri points out that their terrified delivery boy has turned into a human. Rebecca recognizes that the reversion would pose a threat to their kind. She says it must be stopped before it is too late. She then orders Balthazar to find the source of the blood and to do what must be done.
It is Dylan’s birthday. Vanessa and Dylan arrive at their apartment. Their neighbor Susan is fighting with her boyfriend, Tommy. Vanessa kicks his ass and breaks his nose. Outside, ashes from the volcano start to fall from the sky like black snow.
Dylan’s dad calls to greet her a happy birthday and to cancel their weekend plans. Heartbroken Dylan hides in her bedroom closet. Vanessa prepares Dylan’s cake. She then looks for Dylan. An intruder reveals his face and attacks Vanessa. Vanessa defends herself, but he is no match to the feral vampire. He bits him then falls to his knees, vomits blood, and escapes. Vanessa is bleeding. She tells Dylan to look for Susan, call for the police, and call his father. Before taking her last breath, she tells Dylan she loves her.
Doc opens up a cadaver bag to reveal the dead Vanessa. She notices that the lividity is unusual, the body is not cooling, and that rigor has not set in. She concludes Vanessa is not alive, but not dead either. Perplexed, she decides to conduct more examinations and blood work. She calls her sister Grace, who works for the military and tells about her findings. Grace mentions of a classified advisory from the Pentagon and requests for a copy of the results.
Military men arrive at the hospital and talk to Doc about Vanessa’s body. The sky darkens with the ashes. Another volcano erupted. When they reach Vanessa’s body, Doc explains that she is dead and not dead at the same time. The military prepares to transport the body despite Doc’s objections. But the power went off. The cloud ashes are blocking the sun. Streets are in chaos. A patient starts attacking people. Axel and the other marines are ordered to protect Sleeping Beauty until they get a secure position and transport.
Three years later, Vanessa still lies at the hospital in the same operating table. Somewhere else, Dmitri and Rebecca pay a visit to a certain doctor who conducts experiments to solve vampire sterility. The doctor says the woman (referring to Vanessa) who has the abilities of some kind could be very helpful. Dmitri declares that her existence could be the end of the vampires. Rebecca opposes that she could be the future. Dmitri orders Rebecca to find the said woman.
Back at the hospital, supplies are running out. Ted decides that he, Smith, and Gomez go back to their base which is 40 miles away, and recon with whatever weapons and ammunition they could carry. Despite Axel’s protest, they pushed through with the plan. They are outnumbered by the vampires outside the hospital. Smith tries to go back but Doc is closing the door on him. She gets bitten in the arm by one of the ferals before finally closing the door. The ferals then feed on Smith.
Inside the hospital, Axel and Doc try to cut her arm but it is too late. Axel points a gun at the distraught Doc and says she made him promise to shoot her if ever she gets bitten. But Doc changes her mind. She does not want to die. Axel helps her out, straps her down, and promises her that he will keep her safe until they find a cure. Doc then turns into a vampire.