On the day of The Rising, Julius creeps into a room full of sleeping junkies and feeds on one of them. His skin burns whenever the sun hits him. Outside, the ashes from the volcano start to block the sun. Julius then lets out his hand, and for the first time, he is not burning. Now able to walk during the day, he went outside and starts biting any person he sees. One of his victims is Flesh, who turns into a vampire almost instantly and starts killing his own family.
In the present day, the survivors holed up in the hospital talk about Vanessa’s healing powers. Axel is feeding Doc his blood. Someone starts calling for anybody. It is Flesh, the vampire-now-turned-human, who they threw in the garbage chute the night before. He reveals that Vanessa’s blood turned him back to being a human. The surprised Vanessa cannot believe what Flesh just told them. She claims there is nothing special about her.
A commotion outside brings Axel, Vanessa, and the rest of the group to the rooftop. Vampires down the street are taking Wendy as a hostage. They demand that Vanessa be surrendered to them in exchange for Wendy. John, Wendy’s husband, is more than willing to make the trade. Axel, however, objects and shoots Wendy instead. John trips on the wire as he attacks Axel. The turbine that keeps the UV lights running falls on the street. Now without the hospital’s primary source of defense, Axel tells them they only have three hours to live. Axel plans to go on a trip to scavenge parts for the generator. Vanessa goes with him. They leave Mohamad and Sam in-charge.
John suggests to the group that they kill Flesh and Doc before Axel returns. Mohamad and Sam step in to protect them.
Axel and Vanessa arrive at an abandoned ferry. Axel goes underwater to retrieve the part they need. Vanessa stands as a lookout. Ferals attack them. One of them bites Vanessa, vomits blood, and then died.
Back at the hospital, the power goes off. Vampires start attacking the door. Axel and Vanessa arrive but they cannot get in. Flesh goes outside and talks to his former comrades. He tells them he is now human, and that Vanessa caused it. The vampires get scared and fled. Vanessa and Axel brought Wendy’s body inside.
After having seen what the world is like, Vanessa talks to Axel as to what could have been the fate of her daughter Dylan. She asks Flesh why he risked his life to save them. Flesh tells her how he murdered his children as soon as he turned into a vampire, and left his wife with pieces of their children all around her. He tells her how it is like to be a vampire.
After fixing the generator, Axel asks Vanessa to turn Doc back to being human again. Vanessa goes into Doc’s cage and forces her to bite. Doc refuses, so Vanessa bites her instead. Doc passes out.
The vampires who attacked the hospital arrives at Julius’ place. They relay to him what Flesh has said. Julius orders to send word to Dmitri about the news.
Just as when Axel thinks that Doc is dead, she wakes up. Doc is relieved that she is human once again.